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Pre-Surgical Information
Spaying or neutering your pet is a big step! There is a lot to consider
when we are planning your pet’s surgery. Here is some information to help
you make wise decisions.
Click here . . .
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Special LibraryOur Special Library
is a collection of informative articles on a variety of health topics.
Click here . . .
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Discharge InstructionsClick here for
information on how to care for your pet at home.
Click here . . .
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The gastroduodenal effects of buffered aspirin, carprofen,
and etodolac in healthy dogs.
Reimer ME, Johnston SA, Leib MS, Duncan RB Jr,
Reimer DC, Marini M, Gimbert K.
Department of Small Animal Clinical
Sciences, Virginia-Maryland Regional College of Veterinary
Medicine, Virginia Polytechnic Institute and State University,
Blacksburg 24061, USA.
Twenty-four healthy mixed-breed dogs were divided into 4 groups.
Group 1 received a placebo p.o. q12h, group 2 received an
average of 16.5 (15.1-17.8) mg/kg buffered aspirin p.o. q12h,
group 3 received an average of 2.2 (2.0-2.4) mg/kg carprofen p.o.
q12h, and group 4 received an average of 12.8 (11.7-13.8) mg/kg
etodolac p.o. q24h (with a placebo in the PM). All treatments
continued for 28 consecutive days. Gastroduodenal endoscopy was
performed on days -9, 0, 5, 14, and 28. Multiple gastric
biopsies were obtained endoscopically on day -9 to determine
each dog's Helicobacter infection status. Four regions in the
stomach and 1 region in the proximal duodenum were evaluated
endoscopically, and each was assigned a score from 1 to 11.
Scores for each region then were summed to give a total score
for each endoscopic evaluation. Erosions and submucosal
hemorrhages were seen in all dogs receiving aspirin. Only minor
gastric lesions were observed in the carprofen, etodolac, and
control groups. No adverse clinical signs were noted in any dog
given any treatment. Median total score on days 0, 5, 14, and
28, respectively, were as follows: group 1: 5.0, 5.0, 5.0, 5.0;
group 2: 5.0, 27.0, 26.0, 27.5; group 3: 5.0, 5.0, 6.0, 5.0,
group 4: 5.0, 7.0, 5.0, 5.0. There was no significant difference
among dogs receiving carprofen, etodolac, or placebo. The
administration of carprofen, etodolac, or placebo to healthy
dogs resulted in significantly less gastroduodenal lesion
development than in dogs receiving buffered aspirin. |
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