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High Thyroid Levels



High Thyroid levels, also known as Hyperthyroidism, is a common disease of older cats.



Hyperthyroidism is a condition where the thyroid gland makes too much thyroid hormone.  Thyroid hormone regulates the level of metabolism, and hyperthyroid cats have a very fast metabolism. They show a variety of symptoms related to hyper-metabolism including weight loss despite eating a lot, excessive drinking and urination, vomiting, diarrhea, and rapid heart rate.  It is quite common for hyperthyroid cats to also have some degree of kidney dysfunction which is present but hidden by the other symptoms.  Many hyperthyroid cats are also hypertensive.  Without treatment, hyperthyroid cats burn out quite rapidly.   With treatment, they will live longer and do better.

There are three forms of treatment for hyperthyroidism.  One is a surgery, which I feel has too high a complication rate, one is radiation therapy, which is quite expensive and is not available locally, and the third is a medication called methimazole.  While methimazole treatment is not without it’s problems, I feel it I the best choice for most cats.  

Methimazole has the following problems that must be addressed.  The first is that if a cat with hyperthyroidism also has hidden kidney problems, which is actually quite common, the methimazole treatment may make the kidney disease worse.  It is estimated that about 20% of hyperthyroid cats will also have hidden kidney disease.  We must monitor the kidneys as we go with blood tests to make sure we don’t change a bad problem (hyperthyroidism) into a worse one (kidney failure).  

The second issue is that methimazole can damage the bone marrow in a few cats.  Again, we need to monitor the blood as we go to make sure we don’t cause a worse problem.  

The third issue is that about 15% of cats will experience other side-effects with methimazole.  The most common are vomiting and itching.   To minimize these other problems, we start with a low dose and gradually increase.   Most of the problems occur in the first three months of treatment if they are going to occur.

There is also the issue of how we are going to medicate the sick cat.  Pills are the least expensive way, but they can be difficult if not impossible to give.  Tablets cost around 50 cents to $2 a dollar a day, depending on the necessary dose.  The dose it takes is variable, and so we start low and increase until we get the results we want.   For cats that won’t take pills twice a day, there is a gel that can be rubbed on the skin.  This costs more, but is much easier to give.

The schedule goes like this: We start with a low dose of methimazole given once a day for 2 weeks, then increase the dose to every 12 hours for 2 weeks.  At this point we test the blood for adverse events and to see if the dose is high enough.  If the dose is not high enough, we continue to increase the dose gradually, re-testing every 2 weeks, until we get thyroid levels under control.  Then we re-test every 6 months or so. 


Methimazole treatment requires a time and money commitment on the part of the owner, and is not trouble-free.  However, it will increase the affected cat’s  lifespan and increase the quality of life.  The literature shows anywhere from 2 to 4 years extension in life.  It takes a while to see improvement, generally 2 to 6 weeks after we get thyroid levels under control.  While methimazole treatment it is not without it's problems, it is worth it because it will extend the lifespan and improve the quality of life of your cat.